Expresión de búsqueda: DNA GYRASE 
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Descriptor Inglés:   DNA Gyrase 
Descriptor Español:   Girasa de ADN 
Descriptor Portugués:   DNA Girase 
Sinónimos Inglés:   DNA Gyrase A Subunit
DNA Gyrase B Subunit  
Categoría:   D08.811.399.403.741.149
D12.776.097.237
Definición Inglés:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase. 
Combinados Inglés:   DNA Gyrase/antagonists & inhibitors use Topoisomerase II Inhibitors
 
Nota Histórica Inglés:   2002; use DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, use DNA GYRASE 1980-1993; for GYRA PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   36089 
Identificador Único:   D027081 

Ocurrencia en la BVS:
 

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